A Personalized Medicine Approach for Asian Americans with the Aldehyde Dehydrogenase 2*2 Variant
نویسندگان
چکیده
منابع مشابه
Bioactivation of nitroglycerin by the East Asian variant of aldehyde dehydrogenase-2
Background The East Asian variant of mitochondrial aldehyde dehydrogenase (ALDH2) exhibits significantly reduced dehydrogenase, esterase and nitroglycerin (GTN) reductase activities [1]. The small molecule Alda-1 was reported to partly restore low acetaldehyde dehydrogenase activity of this variant [2]. In the present study we compared the wild-type enzyme (ALDH2*1) with the East Asian variant ...
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Background: Precision medicine is a new approach in the field of medical sciences that utilizes the genetic characteristics of each patient along with clinical information to guide decisions related to diagnosis and early treatment of diseases. The Personalized Medicine Research Center, as the only center approved by the Ministry of Health, is working on precision medicine context and producing...
متن کاملDisruption of the coenzyme binding site and dimer interface revealed in the crystal structure of mitochondrial aldehyde dehydrogenase "Asian" variant.
Mitochondrial aldehyde dehydrogenase (ALDH2) is the major enzyme that oxidizes ethanol-derived acetaldehyde. A nearly inactive form of the enzyme, ALDH2*2, is found in about 40% of the East Asian population. This variant enzyme is defined by a glutamate to lysine substitution at residue 487 located within the oligomerization domain. ALDH2*2 has an increased Km for its coenzyme, NAD+, and a decr...
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Revolutionary changes in sequencing technology and the desire to develop therapeutics for rare diseases have led to the generation of an enormous amount of genomic data in the last 5 years. Large-scale sequencing done in both research and diagnostic laboratories has linked many new genes to rare diseases, but has also generated a number of variants that we cannot interpret today. It is clear th...
متن کاملThe Genetic Factors Affecting Drinking Behaviors of Korean Young Adults with Variant Aldehyde Dehydrogenase 2 Genotype
OBJECTIVE We determined whether aldehyde dehydrogenase 2 (ALDH2) activity alters the way in which drinking behaviors are affected by gene polymorphisms of other alcohol-metabolizing enzymes and serotonin-related proteins. METHODS Through a follow-up survey with a cohort comprising 551 university freshmen over a period of 6 years, we examined the genetic factors affecting drinking behaviors. I...
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ژورنال
عنوان ژورنال: Annual Review of Pharmacology and Toxicology
سال: 2015
ISSN: 0362-1642,1545-4304
DOI: 10.1146/annurev-pharmtox-010814-124915